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Side effects

Before doctors are allowed to give you a medicine, it has to go through rigorous safety tests. All medications have the risk of possible side effects, but generally the benefit of giving the medicine outweighs the possible side effects, and usually they can be managed.

Zoladex has now been available in the UK for over 25 years and so the possible side effects are well known. Your doctor should be familiar with the possible side effects and will be able to talk you through them, as well as help you with any if you do get them.

It is also important to know that not everyone will develop side effects. It is impossible to tell who will and who won’t, but in general your doctor will be able to help you if you are affected.

The most common side effects of treatments like Zoladex are caused by low testosterone levels:

  • Hot flushes
  • Sweating (hyperhidrosis)
  • Decrease in sex drive (loss of libido) and impotence
  • There may also be a gradual loss in bone mineral density which puts you at a greater risk of fractures and broken bones

Other common side effects include:

  • Joint pain (arthralgia)
  • Changes in blood pressure
  • A temporary increase in bone pain
  • Gynaecomastia
  • Cardiac failure, myocardial infarction
  • Rash
  • Impaired glucose tolerance
  • Mood changes and depression
  • You may also experience pain, bruising, bleeding, redness or swelling where the injection is given

Normally these side effects are not serious enough to make it necessary to stop treatment and there are lots of things you can do to help you cope. If you are concerned about any side effects you should speak to your doctor.

Each pack of Zoladex comes with an easy to read patient information leaflet which contains a full list of possible side effects and should be read before you start taking your medicine. This patient information leaflet (PIL) can also be accessed by clicking the link to it at the top of the web page.

Yellowcard side effects reporting

You can report any side-effects that you suspect are due to Zoladex treatment using The Medicines and healthcare products Regulatory Agency's (MHRA) "Yellow Card" system:

N.B. AstraZeneca do not own the content of this external website

Reporting of side effects

Like all medicines, Zoladex can cause side effects, although not everybody gets them.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme, Website: By reporting side effects you can help provide more information on the safety of this medicine.

Managing side effects

Read about how to cope with side effects

Coping with Zoladex side effects

GB-6242. Date of Preparation: Sept 2017